FACULTAD
DR. ENRIQUE A. CASTRO


CURRICULUM
LÍNEAS DE INVESTIGACIÓN
PUBLICACIONES
RINCÓN PERSONAL
CURRICULUM
contacto:
-TELÉFONO: 56-2-6864747
-FAX: 56-2-6864744
-E-MAIL: ecastro@puc.cl
grados académico:
- Licenciatura en Química, Universidad Católica de Chile, 1968.
- Ph. D. in Chemistry, Universidad de Exeter, Inglaterra, 1974.
categoría académica:
PROFESOR TITULAR
estadas post-doctorales:
- Universidad de Exeter, Inglaterra, 1982.
- Universidad de Exeter, Inglaterra, 1990.
- Universidad de Exeter, Inglaterra, 1998.
resposabilidades docentes:
- Pregrado: Química Física II
- Postgrado: Cinética Química, Cinética y Mecanismos de Reacción.
LINEAS DE INVESTIGACION
 
áreas o líneas de investigación:
Estudio cinético y mecanístico de reacciones de compuestos carbonilicos y tiocarbonílicos con nucleofilos en solución.
investigación actual:
Cinética y mecanismos de la aminólisis de S-aril tiolbenzoatos en etanol acuoso.
proyectos en curso:
- "Estudio cinético y mecanístico de la aminólisis de aril tiolbenzoatos".
Proyecto FONDECYT Nº 1020524 (2002-2005).

- "Mecanismo de aminólisis de ésteres y carbonatos. Reacción de un polímero". Proyecto FONDECYT Nº 1020538 (2002-2005).
PUBLICACIONES
recientes:
57.- E. A. Castro, M. G. Ruiz, J. G. Santos: "Structure-reactivity correlations in the aminolysis of aryl chloroformates".
Int. J. Chem. Kinet., 33, 281-287 (2001).

58.- E. A. Castro, P. Pavez, J. G. Santos: "Concerted mechanisms of the reactions of methyl aryl carbonates with substituted phenoxide ions".
J.Org.Chem., 66, 3129-3132 (2001).

59.- E. A. Castro, M. Cubillos, J. G. Santos: "Concerted mechanisms of the reactions of 2,4,6-trinitrophenyl methyl carbonate and 2,4,6-trinitrophenyl acetate with secondary alicyclic amines".
J.Org.Chem., 66, 6000-6003 (2001).

60.- E. A. Castro, L. Leandro, N. Quesieh, J. G. Santos: "Kinetics and mechanisms of the reactions of 3-methoxyphenyl, 3-chlorophenyl, and 4-cyanophenyl thionocarbonates with alicyclic amines".
J. Org. Chem., 66, 6130-6135 (2001).

61.- E. A. Castro, M. Angel, D. Arellano, J. G. Santos: "Kinetic study of the phenolysis of bis(4-nitrophenyl) carbonate, bis(4-nitrophenyl) thionocarbonate, and methyl 4-nitrophenyl thionocarbonate".
J.Org.Chem., 66, 6571-6575 (2001).

62.- E. A. Castro, M. Angel, P. Pavez, J. G. Santos: "Kinetic investigation of the phenolysis of phenyl 4-nitrophenyl and phenyl 2,4-dinitrophenyl carbonates".
J.Chem.Soc.,Perkin Trans. 2, 2351-2354 (2001).

63.- E. A. Castro, M. Andujar, P. Campodonico, J. G. Santos: "Kinetics and mechanism of the aminolysis of 4-nitrophenyl and 2,4-dinitrophenyl 4-methylphenyl carbonates in aqueous ethanol".
Int. J. Chem. Kinet., 34, 309-315 (2002).

64.- E. A. Castro, A. Galvez, L. Leandro, J. G. Santos: "Kinetic investigation of the aminolysis of 3-methoxyphenyl 3-nitrophenyl thionocarbonate, 3-chlorophenyl 3-nitrophenyl thionocarbonate and bis(3-nitrophenyl) thionocarbonate".
J.Org.Chem., 67, 4309-4315 (2002).

65.- E. A. Castro, P. Pavez, J. G. Santos: "Kinetics and mechanism of the phenolysis of asymmetric diaryl carbonates".
J.Org.Chem., 67, 4494-4497 (2002).

66.- E. A. Castro, M. Aliaga, P. Campodonico, J. G. Santos: "Kinetics and mechanism of the aminolysis of methyl 4-nitrophenyl, methyl 2,4-dinitrophenyl, and phenyl 2,4-dinitrophenyl carbonatesl".
J.Org.Chem., 67, 8911-8916 (2002).

67.- E. A. Castro, M. Andújar, A. Toro, J. G. Santos: "Kinetics and mechanism of the aminolysis of 4-methylphenyl and 4-chlorophenyl 4-nitrophenyl carbonates in aqueous ethanol"
J.Org.Chem., 68, 3608-3613 (2003).

68.- E. A. Castro, P. Pavez, J. G. Santos: "Kinetics and mechanism of the benzenethiolysis of 2,4-dinitrophenyl and 2,4,6-trinitrophenyl methyl carbonates and S-(2,4-dinitrophenyl) and S-(2,4,6-trinitrophenyl) ethyl thiolcarbonates ".
J.Org.Chem., 68, 3640-3645 (2003).

69.- E. A. Castro, P. Campodonico, A. Toro, J. G. Santos: "Kinetics and mechanism of the aminolysis of 4-methylphenyl and 4-chlorophenyl 2,4-dinitrophenyl carbonates in aqueous ethanol"
J.Org.Chem., 68, 5930-5935 (2003).

70.- E. A. Castro, D. Arellano, P. Pavez, J. G. Santos: "Kinetic study of the phenolysis of O-methyl and O-phenyl O-2,4-dinitrophenyl thiocarbonates and O-ethyl 2,4-dinitrophenyl dithiocarbonate"
J.Org.Chem., 68, 6192-6196 (2003).

71.- E. A. Castro, J. Bessolo, R. Aguayo, J. G. Santos: "Kinetic investigation of the reactions of S-4-nitrophenyl 4-substituted thiobenzoates with secondary alicyclic amines in aqueous ethanol"
J. Org. Chem., 68, 8157-8161 (2003).

72.- E. A. Castro, P. Pavez, J. G. Santos: "Kinetics and mechanism of the benzenethiolysis of O-ethyl S-(2,4-dinitrophenyl) and O-ethyl S-(2,4,6-trinitrophenyl) dithiocarbonates and O-methyl O-(2,4-dinitrophenyl) thiocarbonate".
J. Org. Chem., 68, 9034-9039 (2003).

73.- E. A. Castro, M. Cubillos, M. Aliaga, S. Evangelisti, J. G. Santos: "Kinetic study of the aminolysis and pyridinolysis of O-phenyl and O-ethyl O-(2,4-dinitrophenyl) thiocarbonates. A remarkable leaving group effect".
J. Org. Chem., 69, 2411-2416 (2004).

74.- E. A. Castro, M. Cubillos, J. G. Santos:
"Kinetics and mechanisms of the pyridinolysis of phenyl and 4-nitrophenyl chlorothionoformates. Formation and hydrolysis of 1-(aryloxythiocarbonyl)pyridinium cations"
J. Org. Chem., 69, 4802-4807 (2004).

75.- E. A. Castro, M. Vivanco, R. Aguayo, J. G. Santos:
"Kinetics and mechanism of the pyridinolysis of S-4-nitrophenyl 4-substituted thiobenzoates in aqueous ethanol"
J. Org. Chem., 69, 5399-5404 (2004).

76.- E. A. Castro, M. Aliaga, J. G. Santos:
"Kinetics and mechanism of the pyridinolysis of 4-nitrophenyl and 2,4-dinitrophenyl S-methyl thiocarbonates"
J. Org. Chem., 69, 6711-6714 (2004).

77.- P. R. Campodonico, P. Fuentealba, E. A. Castro, J. G. Santos, R. Contreras:
"Relationships between the electrophilicity index and experimental rate coefficients for the aminolysis of thiolcarbonates and dithiocarbonates"
J. Org. Chem., 70, 1754-1760 (2005).

78.- E. A. Castro, M. Aliaga, J. G. Santos:
"Kinetics and mechanism of the amnolysis of O-aryl S-methyl thiocarbonates"
J. Org. Chem., 70, 2679-2685 (2005).

79.- E. A. Castro, R. Aguayo, J. Bessolo, J. G. Santos:
"Kinetics and mechanism of the pyridinolysis of S-2,4-dinitrophenyl 4-substituted thiobenzoates"
J. Org. Chem., 70, 3530-3536 (2005).

80.- E. A. Castro, R. Aguayo, J. Bessolo, J. G. Santos:
"Kinetics and mechanism of the reactions of S-2,4-dinitrophenyl 4-substituted thiobenzoates with secondary alicyclic amines"
J. Org. Chem., 70, 7788-7791 (2005).

81.- E. A. Castro, M. Gazitua, J. G. Santos:
"Kinetics and Mechanism of the Anilinolysis of Aryl 4-Nitrophenyl Carbonates in Aqueous Ethanol"
J. Org. Chem., 70, 8088-8092 (2005).

anteriores:
1.- E. Castro, R. Jiménez: "The effects of -radiation on aqueous solutions of 2'-3'-urydilic acid".
Photochem.Photobiol.,7, 721-726 (1968).

2.- E.A. Castro, R.B. Moodie: "Pyridinolysis of methyl chloroformate and the interpretation of curved Bronsted plots in nucleophilic reactions".
J.Chem.Soc.,Chem.Comm., 828-829 (1973).

3.- E.A. Castro, R.B. Moodie : "Kinetics of hydrolysis and aminolysis of methyl chloroformate in aqueous solution".
J.Chem.Soc.,Perkin Trans.2, 658-661 (1974).

4.- P.M. Bond, E.A. Castro, R.B. Moodie : "Kinetics of reaction of substituted pyridines and oxygen anions with methyl chloroformate in aqueous solution".
J.Chem.Soc.,Perkin Trans.2, 68-72 (1976).

5.- E.A. Castro, F.J. Gil : "Curved Bronsted plot in the pyridinolysis of 2,4-dinitrophenyl methyl carbonate. Comparison of leaving group abilities between pyridines and phenolates".
J.Am.Chem.Soc., 99, 7611-7612 (1977).

6.- E.A. Castro, M. Freudenberg : "Bronsted plots in the reactions of 2,4-dinitrophenyl acetate and methyl phenyl carbonate with substituted pyridines".
J.Org.Chem., 45, 906-910 (1980).

7.- C. Castro, E. A. Castro : "Nonlinear structure-reactivity correlation in the pyridinolysis of acetic anhydride".
J.Org.Chem., 46, 2939-2943 (1981).

8.- E.A. Castro, R. Cortés,J.G. Santos,J.C. Vega: "Kinetics and mechanism of the reaction of carbon disulfide with piperidine in ethanol".
J.Org.Chem., 47, 3774-3777 (1982).

9.- E.A. Castro, G.B. Steinfort : "Kinetics and mechanism of the pyridinolysis of 2,4-dinitrophenyl p-nitrobenzoate".
J.Chem.Soc.,Perkin Trans. 2, 453-457 (1983).

10.- E.A. Castro, S. Peña, J.G. Santos, J.C. Vega : "Kinetics and mechanism of the addition of amines to carbon disulfide in ethanol".
J.Org.Chem., 49, 863-866 (1984).

11.- E.A. Castro, R.B. Moodie, P.J. Sansom : "The kinetics of hydrolysis of methyl and phenyl isocyanates".
J.Chem.Soc.,Perkin Trans.2, 737-742 (1985).

12.- E.A. Castro, B. Meneses, J.G. Santos, J.C. Vega : "Kinetics and mechanism of the reactions of S-ethoxycarbonyl O-ethyl dithiocarbonate with O-ethyl xanthate and O-ethyl thiocarbonate ions".
J.Org.Chem., 50, 1863-1866 (1985).

13.- E.A. Castro, C.L. Santander : "Nonlinear Bronsted-type plot in the pyridinolysis of 2,4-dinitrophenyl benzoate in aqueous ethanol".
J.Org.Chem., 50, 3595-3600 (1985).

14.- E.A.Castro, J.L.Valdivia : "Linear free-energy relationship in the pyridinolysis of 2,4-dinitrophenyl p-chlorobenzoate in ethanol aqueous solution".
J.Org.Chem., 51, 1668-1672 (1986).

15.- E.A. Castro, M.T. Borquez, P.M. Parada : "Solvent effect on the relative nucleofugalities of pyridines and phenoxide ions : Bronsted-type plots in the pyridinolysis of 2,4-dinitrophenyl methyl carbonate and 2,4-dinitrophenyl acetate in aqueous ethanol".
J.Org.Chem., 51, 5072-5077 (1986).

16.- E. A. Castro, C. Ureta: "Solvent effect on the relative nucleofugalities of pyridines and chloride ion from a tetrahedral intermediate".
J.Chem.Res.(S), 358-359 (1987).

17.- E. A. Castro, M. C. Becerra : "Linear free-energy relationship in the pyridinolysis of 2,4-dinitrophenyl p-cyanobenzoate in aqueous ethanol".
Bol.Soc.Chil.Quim., 33, 67-75 (1988).

18.- E. A. Castro, N. E. Alvarado, S. A. Peña, J. G. Santos : "Kinetics and mechanism of the aminolysis of S-ethoxycarbonyl O-ethyl dithiocarbonate and related pyrothiocarbonates".
J.Chem.Soc.Perkin Trans. 2, 635-641 (1989).

19.- E. A. Castro, C. Ureta : "Structure-reactivity correlations in the aminolysis of phenyl and p-nitrophenyl thiolacetates".
J.Org.Chem.,54, 2153-2159 (1989).

20.- E. A. Castro, C. Ureta : "Kinetics and mechanism of the reactions of 2,4-dinitrophenyl acetate with secondary alicyclic amines. Different nu- cleofugalities of alicyclic amines and pyridines from a tetrahedral intermediate".
J.Org.Chem., 55, 1676-1679 (1990).

21.- E. A. Castro, C. Ureta : "Kinetics and mechanism of the aminolysis of 2,4-dinitrophenyl and 2,4,6-trinitrophenyl thiolacetates".
J.Chem.Soc.Perkin Trans. 2, 63-68 (1991).

22.- E. A. Castro, F. Ibáñez, M. Salas, J. G. Santos : "Concerted mechanism of the aminolysis of O-ethyl S-(2,4-dinitrophenyl) thiocarbonate".
J.Org.Chem., 56, 4819-4821 (1991).

23.- M. Cabrera, E. A. Castro, M. Salas, J. G. Santos, P. Sepúlveda: "Kinetics and mechanism of the aminolysis of O-ethyl S-aryl dithiocarbonates".
J.Org.Chem., 56, 5324-5328 (1991).

24.- E. A. Castro, F. Ibáñez, J. G. Santos, C. Ureta: "Kinetics and mechanism of the aminolysis of phenyl dithioacetate in aqueous solution".
J.Chem.Soc. Perkin Trans. 2, 1919-1924 (1991).

25.- E. A. Castro : "About the pyridinolysis of 2,4-dinitrophenyl acetate in 50 % v/v acetonitrile - water".
Indian J. Chem. A, 31-32 (1992).

26.- E. A. Castro, F. Ibáñez, S. Lagos, M. Schick, J. G. Santos : "Kinetics and mechanism of the pyridinolysis of 2,4,6-trinitrophenyl acetate and 2,4,6-trinitrophenyl methyl carbonate".
J.Org.Chem., 57, 2691-2694 (1992).

27.- E. A. Castro, F. Ibáñez, J. G. Santos, C. Ureta: "Kinetics and mechanism of the aminolysis of 4-nitrophenyl dithioacetate".
J.Org.Chem., 57, 7024-7028 (1992).

28.- E. A. Castro, F. Ibáñez, A. M. Saitua, J. G. Santos: "Kinetics and mechanism of the reactions of anilines and secondary alicyclic amines with 2,4-dinitrophenyl methyl carbonate".
J.Chem.Res.(S), 56-57 (1993).

29.- E. A. Castro, F. Ibáñez, M. Salas, J. G. Santos, P. Sepúlveda : "Kinetics and mechanism of the aminolysis of 2,4-dinitrophenyl and 2,4,6-trinitrophenyl O-ethyl dithiocarbonates".
J.Org.Chem., 58, 459-463 (1993).

30.- E. A. Castro, F. Ibáñez, J. G. Santos, C. Ureta : "Kinetics and mechanism of the aminolysis of phenyl thionoacetate in aqueous solution".
J.Org.Chem., 58, 4908-4912 (1993).

31.- E. A. Castro, M. Cubillos, F. Ibáñez, I. Moraga, J. G. Santos : "Structure-reactivity relationships in the aminolysis of O-ethyl S-aryl dithiocarbonates in aqueous solution".
J.Org.Chem., 58, 5400-5404 (1993).

32.- E.A. Castro, M. Salas, J.G. Santos : "Concerted mechanism of the reactions of secondary alicyclic amines with O-ethyl S-(2,4,6-trinitrophenyl) thiocarbonate".
J.Org.Chem., 59, 30-32 (1994).

33.- E. A. Castro, M. Cubillos, G. Muñoz, J. G. Santos : "Concerted mechanism of the aminolysis of 2,4,6-trinitrophenyl O-ethyl dithiocarbonate in aqueous ethanol".
Int.J.Chem.Kinet., 26, 571-575 (1994).

34.- E. A. Castro, M. Cubillos, J. G. Santos : "Stepwise mechanism of the aminolysis of O-ethyl S-(4-nitrophenyl) thiocarbonate".
J.Org.Chem., 59, 3572-3574 (1994).

35.- E. A. Castro, M. Cabrera, J. G. Santos : "Kinetics and mechanism of the aminolysis of O-ethyl S-phenyl dithiocarbonate in aqueous ethanol".
Int.J.Chem.Kinet., 27, 49-57 (1995).

36.- E. A. Castro, G. Muñoz, M. Salas, J. G. Santos : "Stepwise mechanisms of the aminolyses of 4-nitrophenyl and 2,4-dinitrophenyl O-ethyl dithiocarbonates in aqueous ethanol".
Int.J.Chem.Kinet., 27, 987-995 (1995).

37.- E. A. Castro, J. G. Santos : "Estudio cinético de la reacción de disulfuro de carbono con pirrolidina en medio etanol acuoso".
Anales ,91, 706-710 (1995).

38.- E. A. Castro, M. Cubillos, J. G. Santos : "Kinetics and mechanism of the aminolysis of phenyl and 4-nitrophenyl ethyl thionocarbonates".
J.Org.Chem., 61, 3501-3505 (1996).

39.- E. A. Castro, M. I. Pizarro, J. G. Santos : "Kinetics and mechanism of the pyridinolysis of O-ethyl S-aryl thiocarbonates in aqueous solution".
J.Org.Chem., 61, 5982-5985 (1996).

40.- E. A. Castro, M. Cabrera, J. G. Santos : "Structure-reactivity correlation in the reactions of pyrrolidine with O-ethyl S-aryl dithiocarbonates in aqueous ethanol".
Int.J.Chem.Kinet., 29, 113-117 (1997).

41.- E. A. Castro, C. A. Araneda, J. G. Santos : "Kinetics and mechanism of the pyridinolysis of 2,4-dinitrophenyl and 2,4,6-trinitrophenyl O-ethyl dithiocarbonates".
J.Org.Chem., 62, 126-129 (1997).

42.- E. A. Castro, M. Cubillos, J. G. Santos, J. Tellez : "Kinetics and mechanism of the pyridinolysis of alkyl aryl thionocarbonates".
J.Org.Chem., 62, 2512-2517 (1997).

43.- E. A. Castro, M. Cubillos, J. G. Santos : "Kinetics and mechanism of the aminolysis of phenyl and 4-nitrophenyl chlorothionoformates".
J.Org.Chem., 62, 4395-4397 (1997).

44.- E. A. Castro, J. G. Santos, J. Téllez, M. I. Umaña : "Structure-reactivity correlations in the aminolysis and pyridinolysis of bis(phenyl) and bis(4-nitrophenyl) thionocarbonates".
J.Org.Chem., 62, 6568-6574 (1997).

45.- E. A. Castro, A. Hormazábal, J. G. Santos : "Concerted mechanism of the reactions of 2,4-dinitrophenyl 4-cyanobenzoate with secondary alicyclic amines in aqueous ethanol".
Int.J.Chem.Kinet., 30, 267-272 (1998).

46.- E. A. Castro, M. Cubillos, J. G. Santos : "Concerted mechanisms of the reactions of phenyl and 4-nitrophenyl chlorothionoformates with substituted phenoxide ions".
J.Org.Chem., 63, 6820-6823 (1998).

47.- E. A. Castro, L. Leandro, P. Millán, J. G. Santos: "Kinetics and mechanism of the reactions of anilines with ethyl S-aryl thiocarbonates".
J.Org.Chem., 64, 1953-1957 (1999).

48.- E. A. Castro, P. Pavez, J. G. Santos: "Concerted mechanisms of the reactions of ethyl S-aryl thiocarbonates with substituted phenoxide ions".
J.Org.Chem., 64, 2310-2313 (1999).

49.- E. A. Castro, M. G. Ruiz, S. Salinas, J. G. Santos: "Kinetics and mechanism of the aminolysis of phenyl and 4-nitrophenyl chloroformates in aqueous solution".
J.Org.Chem., 64, 4817-4820 (1999).

50.- E. A. Castro, C. Saavedra, J. G. Santos, M. I. Umaña: "Kinetics and mechanism of the aminolysis of phenyl and methyl 4-nitrophenyl thionocarbonates".
J.Org.Chem., 64, 5401-5407 (1999).

51.- E. A. Castro, M. Cubillos, J. G. Santos: "Structure-reactivity correlations in the aminolysis of ethyl S-aryl thiolcarbonates".
J.Org.Chem., 64, 6342-6346 (1999).

52.- E. A. Castro, P. Muñoz, J. G. Santos: "Kinetics and mechanism of the reactions of quinuclidines with ethyl S-aryl thiolcarbonates".
J.Org.Chem., 64, 8298-8301 (1999).

53.- E. A. Castro, M. Cubillos, J. G. Santos, E. I. Bujan, M. V. Remedi, M. A. Fernandez, R. H. de Rossi: "Mecanism of the alkaline hydrolysis of O-ethyl 2,4,6-trinitrophenyl thiol and dithio carbonates".
J.Chem.Soc.Perkin Trans. 2, 2603-2607 (1999).

54,- E. A. Castro: "Kinetics and mechanisms of reactions of thiol, thiono, and dithio analogues of carboxylic esters with nucleophiles".
Chem. Reviews 99, 3505-3524 (1999).

55.- E. A. Castro, L. Leandro, J. G. Santos: "Kinetics and mechanism of the aminolysis of O-phenyl 4-nitrophenyl dithiocarbonate in aqueous ethanol".
Int.J.Chem.Kinet., 31, 839-845 (1999).

56.- E. A. Castro, P. García, L. Leandro, N. Quesieh, A. Rebolledo, J. G. Santos: "Kinetics and mechanisms of the reactions of 4-nitro and 3-nitro-phenyl 4-methylphenyl thionocarbonates with alicyclic amines and pyridines".
J. Org. Chem., 65, 9047-9053 (2000).